The group of Tong et al. found that the concentrations of several mRNAs, including the mRNAs NR4A2 encoding nuclear receptor related 1 protein (NURR1) and EMP1 encoding epithelial membrane protein 1 (EMP1), were significantly altered in the maternal circulation in pregnancies with “complicated preterm birth” (i.e., IUGR and birth before 34 weeks gestation) [40]. This evidence concerns the gene NR4A2 and fetal growth restriction.