Indeed, it was shown in head and neck squamous cell carcinoma (HNSCC) that the interaction between the EphB4 receptor and ephrin–B2 ligand, on the membranes of tumor cells interacting with their immune neighbors, affects the numbers of intratumoral immunosuppressive regulatory T cells (Tregs) [421]. Here, EFNB2 is linked to head and neck squamous cell carcinoma.