Accordingly, the theoretical irreversible functional loss of Piezo2 on proprioceptive terminals [41] and the resultant progressive loss of proprioceptive protection, not to mention acidosis, glutamate mishandling, and hypoxia, could contribute to the observed upregulated expression of ASIC2 and altered distribution of CA1 on the endoplasmic reticulum membranes of motor neurons in ALS. Here, PIEZO2 is linked to amyotrophic lateral sclerosis.