Another in vitro model, in which Resveratrol is capable of preventing thimerosal-induced cell death by Sirtuin 1 (SIRT1) activation [118], is indicative of Piezo1 involvement in the ALS pathomechanism, since Piezo1 could mediate the SIRT1-HIF1α glucose metabolism pathway [119]. The gene discussed is HIF1A; the disease is amyotrophic lateral sclerosis.