PIEZO1 and primary myelofibrosis: Stiffness sensation by Piezo1 was found to be associated with upregulation of the expression of the channel in MKs, as proven by culturing these cells in a 3D culture medium of different stiffness and by its enhanced MK expression in the case of primary myelofibrosis (PMF), a disease characterized by bone marrow fibrosis and augmented stiffness of the extracellular matrix (ECM) [38].