To this end, we investigated cancer cell lines PANC-1 and SW-620 to test the hypothesis of the functional selectivity of CB1 GPCR agonist to form heteromers with NMBR to initiate the molecular organizational signaling platform of novel Neu1 and MMP-9 crosstalk in alliance with RTKs on the cell surface (Figure 2A). This evidence concerns the gene MMP9 and cancer.