CHRNA7 and synucleinopathy: In further support of the contention that targeting nAChRs may be a novel therapeutic strategy for PD treatment [99,206], it was recently reported that nicotine’s prevention of synucleinopathies or α-Syn toxicity may be due to its interaction with α7nAChRs and inhibition of apoptosis as well as interaction with synaptic vesicle glycoprotein [201,207].