Wang et al., (2022) demonstrated a direct connection between EGF signaling deregulation and metabolic shifting toward aerobic glycolysis through the T405/S406 O-GlcNAcylation of pyruvate kinase M2 (PKM2) in breast cancer MCF-7 cells, non-small-cell lung cancer A549, and glioblastoma U251 cells [154]. The gene discussed is PKM; the disease is glioblastoma.