NfL levels were compared to, and percentiles derived from, recently developed NfL reference ranges.<h4>Results</h4>Plasma NfL was significantly elevated in 11 patients with NPC compared to 25 controls (mean 17.1 vs. 7.4 pg/ml, <i>p</i> < 0.001), and reference ranges (all >98<sup>th</sup> percentile). Here, NEFL is linked to nasopharyngeal carcinoma.