CASP3 and colorectal carcinoma: It has been reported that F. nucleatum intervention can activate the Hippo pathway in CRC cells.19 Moreover, Yes-associated protein (YAP) can act as a cotranscription factor in the BCL2 promoter region to promote the transcription of BCL2 in CRC cells.20,21 Inhibition of the YAP pathway was shown to promote the cleavage of Caspase-3.22 Therefore, we hypothesized that F. nucleatum may regulate the downstream BCL2-induced pyroptosis pathway by activating the YAP pathway.