GSDME and colorectal carcinoma: Lobaplatin treatment could downregulate the expression of BCL2 in CRC.16 Triclabendazole can activate pyroptosis by modulating the level of the apoptotic protein BCL2, enhancing the cleavage of Caspase-3 and GSDME.18 Western blotting results revealed that F. nucleatum could ameliorate the reduction in BCL2 protein levels induced by chemotherapy drugs (Figures 2d, e, Figure S1B).