CASP3 and colorectal carcinoma: Wang et al. identified that GSDME could transform Caspase-3 mediated apoptosis induced by chemotherapy drugs into pyroptosis.13 Under the stimulation of chemotherapy, GSDME can be cleaved specifically by cleaved Caspase-3, resulting in the generation of membrane-penetrating GSDME-N fragments that induce pyroptosis.13 In CRC cells, lobaplatin has been shown to mediate pyroptosis through GSDME activation induced by Caspase-3.16 Therefore, we hypothesized that F. nucleatum could downregulate the GSDME-related pyroptosis induced by chemotherapy drugs to induce chemoresistance.