Lobaplatin treatment could downregulate the expression of BCL2 in CRC.16 Triclabendazole can activate pyroptosis by modulating the level of the apoptotic protein BCL2, enhancing the cleavage of Caspase-3 and GSDME.18 Western blotting results revealed that F. nucleatum could ameliorate the reduction in BCL2 protein levels induced by chemotherapy drugs (Figures 2d, e, Figure S1B). This evidence concerns the gene CASP3 and colorectal carcinoma.