In an azoxymethane-induced CRC model and adenomatous polyposis coli mice, immunization with CDC25B- and COX2-based vaccines, but not with RCAS1- and FASCIN1-based vaccines, significantly suppressed colorectal tumors compared with controls, whereby treated mice developed a significantly lower number of tumors in both CRC models. The gene discussed is EBAG9; the disease is colorectal carcinoma.