The tumor necrosis factor-α (TNF-α), a pleiotropic cytokine implicated in various conditions such as infections, malignancies, and inflammatory/autoimmune diseases, and the vascular endothelial growth factor (VEGF), a key regulator of physiological and tumor angiogenesis, were chosen as the soluble proteins to be targeted for degradation. The gene discussed is TNF; the disease is autoimmune disease.