Moreover, Wueest and Konrad (40) have already highlighted that IL-6 signaling in adipocytes is involved in the development of insulin resistance associated with obesity and hepatic steatosis by inducing the release of free fatty acids and leptin from adipocytes, thus affecting hepatic metabolism and pancreatic β-cell function. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.