Of the identified immune traits contributing to gastric cancer risk, the three exhibiting the highest OR were “CD45 on CD4+” (IVW p <0.001; OR=1.394, 95%CI [1.154 ~ 1.683]), “CD28+ DN (CD4-CD8-) AC” (IVW p =0.010; OR=1.296, 95%CI [1.063 ~ 1.581]), and “TD DN (CD4-CD8-) AC” (IVW p =0.002; OR=1.208, 95%CI [1.071 ~ 1.362]). Here, CD28 is linked to gastric cancer.