Within the immune traits associated with colon cancer risk, the three with the highest ORs were “CD45 on CD4+” (IVW p=0.043; OR=1.107, 95%CI [1.003 ~ 1.221]), “EM DN (CD4-CD8-) %T cell” (IVW p=0.003; OR=1.100, 95%CI [1.032 ~ 1.172]), and “HLA DR++ monocyte %leukocyte” (IVW p=0.048; OR=1.093, 95%CI [1.001 ~ 1.194]). The gene discussed is CD8A; the disease is malignant colon neoplasm.