STING1 and neoplasm: As inflammation is one of the key factors for inducing tumorigenesis, in addition to the fact that STING was shown to promote the tumorigenesis of lung cancer tumors with low antigenicity via indoleamine 2,3 dioxygenase (IDO) activation, it would be reasonable to hypothesize that the partial anti-tumor effect of DMXAA is due to its suppressive activity on STING-induced inflammatory responses in humans (18, 19).