The chemotherapeutic agent DMXAA exerts potent anti-tumor activity in mouse tumor models through various mechanisms, including the disruption of tumor vasculature, nitric oxide induction from tumor-associated macrophages, and the induction of tumoricidal cytokines such as TNFα and type I IFNs, the latter in a STING-dependent manner (13, 15 and 16). Here, STING1 is linked to neoplasm.