Notably, even at 10 μg/ml, HHMX strongly suppressed over-functional STING-mediated promoter activation and cytokine production, suggesting that HHMX may have a therapeutic potential for STING-related autoinflammatory diseases such as SAVI (Figures 5A, B). Here, STING1 is linked to STING-associated vasculopathy with onset in infancy.