IL4 and Alzheimer disease: As predicted, the mRNA levels of cytokines produced by Th1 (Ifnγ), Th2 (Il4, Il5, Il13, and Il31), and Th17 (Il17a) were markedly reduced in the skin of IMP-treated AD-like skin lesion mice, providing clear evidence that IMP antagonizes T-cell responses during AD onset (Figure 3C).