Moreover, significant inhibition of mast cell expansion, characterized by eosinophils with the single-F+CD11b+ phenotype and mast cells with c-kit+FcεRIA+ phenotype, was also observed in AD-like skin lesion mice treated with IMP and Rapa compared to that in the untreated AD-like skin lesion mice (Figure 2). This evidence concerns the gene TRERF1 and Alzheimer disease.