Flow cytometric analysis showed that the frequency of myeloid cell infiltration in the skin was significantly reduced in a dose-dependent manner by the recruitment of neutrophils with the CD11b+Ly6G+ phenotype and macrophages with the CD11b+F4/80+ phenotype in the IMP-treated AD-like skin lesion mice compared to that in the AD-like skin lesion mice. This evidence concerns the gene ITGAM and Alzheimer disease.