We found that the number of Th1 (CD4+IFN-γ+), Th2 (CD4+IL-4+), and Th17 (CD4+IL-17A+) cells were significantly reduced in the skin cells of both IMP- and Rapa-treated AD-like skin lesion mice, whereas this was not observed in AD-like skin lesion mice treated with Rapa alone (Figures 3A, B). Here, CD4 is linked to Alzheimer disease.