SOCS3 and chronic obstructive pulmonary disease: The expression of the SOCS3 recognized regulators miRNA-19a-3p and miRNA-221-3p in BAL EVs was increased in smokers without COPD when compared to smokers with COPD [19 (2–53) vs. 3 (0.6–8), p = 0.03 and 3 (0.005–9.6) vs. 0.2 (0.08–0.7), p = 0.05, respectively; Figures 5A, B].