SOCS3 and chronic obstructive pulmonary disease: Macrophage-derived EVs expressing SOCS3+ (CD14+SOCS3+) were increased in smokers with COPD [33 (21–174) events/μL] compared to smokers without COPD [16 (8–37) events/μL; p = 0.03] and non-smokers [9 (7–21) events/μL; p = 0.003, Figures 4A, B].