MBP and multiple sclerosis: Since its discovery, serum/cerebrospinal fluid MBP or Myelin Basic Protein has been regarded as a marker of brain tissue injury in TBI, cerebrovascular accidents, multiple sclerosis (MS), intracranial tumors, and CNS infections (29); however, its expression was also found in the peripheral nervous system (30) which limits the TBI diagnostic potential of this protein in polytrauma patients.