Our results showed that serum Lp-PLA2 activity level in PD-CI patients was positively correlated with TC (r = 0.346, p = 0.014), LDL (r = 0.382, p = 0.006), sdLDL (r = 0.349, p = 0.010), and ApoB (r = 0.449, p < 0.001). The gene discussed is APOB; the disease is Parkinson disease.