AKT1 and cancer: Additionally, the significantly enriched KEGG pathways based on the Group R vs. Group S comparison were the PI3K-Akt signaling pathway, human papillomavirus infection, the FoxO signaling pathway, viral carcinogenesis, apoptosis, peroxisomes, central carbon metabolism in cancer, tuberculosis, hepatitis C, natural killer cell-mediated cytotoxicity, and pathogenic E. coli infection (Figure 5A).