The activation of AGE-RAGE signaling pathway can also promote the fibrosis process of kidney tissue, which leads to the increase of collagen deposition and the proliferation of extracellular matrix, which leads to glomerular sclerosis, interstitial fibrosis and tubulointerstitial scar formation, thus affecting the normal structure and function of kidney. The gene discussed is RENBP; the disease is glomerulosclerosis.