Al-Mutair and his colleagues reported that excessive lung inflammation, increased pulmonary capillary permeability and alveolar fluid accumulation induced by SARS-CoV-2 were associated with ARDS, for this reason, some ARDS patients required respiratory assistance, particularly diagnosed in patients with severe COVID-19, and this could be due to increased levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) found in these patients [80]. This evidence concerns the gene TNF and COVID-19.