IL-1α and IL-1β are known to induce an inflammatory response and acute immune response, including the proliferation and recruitment of macrophages and neutrophils to the infection site (Sims and Smith, 2010; McKinnon et al., 2018; Palazon Riquelme and Lopez Castejon, 2018; Kaneko et al., 2019; Cavalli et al., 2021). Here, IL1A is linked to infection.