Through PPI protein network analysis and Cytoscape software visualization, we can see that the key targets of Tan-IIA on human neuroblastoma are GRB2, SRC, EGFR, PTPN1, ESR1, IGF1, MAPK1, PIK3R1, AKT1, IGF1R and so on. This evidence concerns the gene ESR1 and neuroblastoma.