Similarly, the abnormal expression of PTPN1 in gastric cancer, ovarian cancer, colon cancer and other tumors can promote cell proliferation, colony formation and migration, while reduce the apoptosis of cancer cell lines (Feng et al., 2015; Yu et al., 2019), and the overexpression of PTPN1 is associated with poor prognosis (Leslie and Foti, 2011). This evidence concerns the gene PTPN1 and malignant colon neoplasm.