Univariate Cox regression suggested that high RARRES1 level had a protective role in diffuse large B-cell lymphoma (DLBC, p = 0.006), mesothelioma (MESO, p = 0.005), skin cutaneous melanoma (SKCM, p = 0.002) and Sarcoma (SARC, p = 0.004), while it was associated with shorter overall survival in ovarian cancer (OV, p = 0.008), pancreatic adenocarcinoma (PAAD, p = 0.027), uterine corpus endometrial carcinoma (UCEC, p < 0.001), glioblastoma multiforme (GBM, p < 0.001), kidney renal clear cell carcinoma (KIRC, p < 0.001), and lower grade glioma (LGG, p < 0.001) (Figure 6D). This evidence concerns the gene RARRES1 and cutaneous melanoma.