SPP1 and neoplasm: In myeloid cells (Figures 3C, D), we identified three tumor-associated macrophages (TAMs) clusters (c0:TAM_SPP1/TREM2, c1:TAM_FOLR2, c2:TAM_CXCL9) according to the expression of SPP1, TREM2, FOLR2, and CXCL9; monocyte (c3:Mono) marked by FCN1 and IL1B expression; plasmacytoid dendritic cells (pDC) with high expression of LILR44 and TCF4; three conventional dendritic cells (cDCs) characterized by high expression of either CLEC9A (c5:cDC1), CD1C (c6:cDC2), or LAMP3 (c7:cDC3); and a MKI67 high cycling cluster (c9:Cycling myeloid).