In the present study, we systematically profiled the cellular components of the TME in TNBC by scRNA-seq data, as well as identified signature genes of pro-inflammatory immune cells, including CXCL13+ tumor-reactive T cells, activated T cells, effector T cells, CXCL9+ TAMs, NK cells, and cDC1. The gene discussed is CXCL13; the disease is neoplasm.