The pro-inflammatory genes in the inflammatory cascade studied were the nuclear factor kappa B (NF-kβ), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF- α), cyclooxygenase-2 (COX-2) and oncogene ErbB2 expression in the non-affected pancreas from patients with PC and CP patients as controls were subjected to comparative gene expression analysis by a case-control study. The gene discussed is PTGS2; the disease is pachyonychia congenita.