CDKN2A and breast cancer: Specifically, the chemokine (C-C motif) ligand 18 (CCL18), which is mainly produced by tumor-associated macrophages and has been linked to the formation of metastases in BC, was found to increase the expression of ARF6 and the phosphorylated form of its downstream effector AMAP1, an ARF GAP, in MCF-7 cells (Huang et al., 2022).