Several lncRNA transcripts with cardiac-specific roles have been identified, such as Kcnq1ot1 in ion channel activity (Korostowski et al., 2012), MIAT(myocardial infarction-associated transcript) in myocardial infarction (Ishii et al., 2006), ANRIL in atherosclerosis (Holdt et al., 2010), Carl (cardiac apoptosis-related lncRNA) in regulating cell death in cardiomyocytes (Wang et al., 2014b), DMK1 in myotonic muscular dystrophy (Mahadevan et al., 2006; Yadava et al., 2008) and Pvt1 in hypertrophy (Yu et al., 2015). Here, KCNQ1OT1 is linked to atherosclerosis.