For example, in gastric cancer, CXCL8 promotes an immunosuppressive microenvironment by inducing macrophages (33).Targeting the CXCL8-CXCR2 axis may hinder dendritic cell activation or recruitment, which in turn exerts a critical anti-tumor effect on colorectal cancer (34). The gene discussed is CXCR2; the disease is colorectal cancer.