Although recently, we have shown that oral administration of aspirin protects mice from EAE (an animal model of MS) [19], reduces plaques and upregulates hippocampal plasticity in an animal model of AD [22, 23] and increases tyrosine hydroxylase in the brain of A53T mouse model of PD [75], oral aspirin has some side effects. The gene discussed is TH; the disease is Alzheimer disease.