The immune system may be the potential mechanism; IL‐6 was reported to be implicated in the pathogenesis of sarcopenia and the binding of IL‐6 to IL‐6 receptor could initiate gp130‐dependent signaling pathway which would activate ERK1/2 (Fix et al., 2019; Nelke et al., 2019). The gene discussed is MAPK3; the disease is sarcopenia.