ID4 was enriched in 21 KEGG items, with TOP 10 pathway as Graft versus host disease, Allograft rejection, Autoimmune thyroid disease, Primary immunodeficiency, Intestinal immune network for IgA production, Type I diabetes mellitus, Spliceosome, Basal cell carcinoma, Asthma, Wnt signaling pathway (Figure 10b, Table 6, Table S21–22). The gene discussed is CD79A; the disease is autoimmune thyroid disease.