In addition, resveratrol was reported to improve overactive bladder via downregulation of the protein expression level of SCF, c-Kit and p-AKT in the bladder of rats with chronic prostatitis (CP), and the combination of resveratrol and solifenacin strengthened the improvement in overactive bladder, indicating potential pharmacological synergy as a theraputic strategy for CP patients [167]. This evidence concerns the gene AKT1 and overactive bladder.