NF1 is a dominantly inherited genetic disorder caused by PGV in the tumor suppressor gene NF1. Individuals with NF1 characteristically develop benign and malignant tumors of the central and peripheral nervous systems (gliomas of the optic pathway, glioblastomas, and malignant peripheral nerve sheath tumors) [52]. Here, NF1 is linked to malignant peripheral nerve sheath tumor.