Notably, EGFR is a well characterized surface molecule for epithelial cells in many types of cancers and, accordingly, we and other groups worldwide have successfully applied the EGFR CL4 aptamer as tumor ligand to decorate nanocarriers actively targeted to TNBC [24–27, 69, 70], hepatocellular carcinoma [68], osteosarcoma [65] and chordoma [71]. Here, EGFR is linked to neoplasm.