EGFR and neoplasm: In order to specifically address Iren-AuSiO2_COOH to target tumor/stromal cells, conjugation with the EGFR CL4 (Iren-AuSiO2_CL4) or PDGFRβ Gint4.T (Iren-AuSiO2_Gint4.T) aptamers, and dual functionalization with both CL4 and Gint4.T (Iren-AuSiO2_CL4_Gint4.T) were performed.