Moreover, in the context of highly aggressive human cancers, including MES-TNBC [39, 72] and different glioblastoma (GBM) subtypes [73], being characterized by a strong PDGFRβ-positivity on tumor cells and self-renewing stem cells, Iren-AuSiO2_CL4_Gint4.T may act in a synergistic way by targeting either EGFR and PDGFRβ on the epithelial tumor cells and PDGFRβ in the stroma components. Here, EGFR is linked to glioblastoma.