Specifically, for tumor cell targeting we used the CL4 2′Fluoro-pyrimidines (2′F-Py) RNA aptamer (Kd, 10 nM; 39 nt) [19], capable of binding at high efficacy to the extracellular domain of epidermal growth factor receptor (EGFR), one of the most potent oncoprotein of human cancer. This evidence concerns the gene EGFR and neoplasm.