TRPM2 and metastatic neoplasm: In addition, we obtained similar results in the lung metastasis model; luciferase activity in metastatic tumors (Fig. 2E), the number of pulmonary metastatic nodules (Fig. 2G), and the microvascular density of the nodules (Fig. 2I) were all remarkably increased in the TRPM2-AS overexpression group, whereas in the TRPM2-AS knockdown group, the advantages of luciferase activity, pulmonary metastasis, and increased nodule vascular density were abolished (Fig. 2F, H, J).