Just as acting as a microRNA sponge is critical for many lncRNAs to exert regulatory functions in tumor progression, TRPM2-AS has also been shown to sponge microRNA-138-5p to activate epidermal growth factor receptor (EGFR) and phosphatidylinositol 3-kinase (PI3K)/AKT signaling to promote the malignant biological behavior of non-small cell lung cancer (NSCLC) cells [40]. This evidence concerns the gene TRPM2 and neoplasm.