According to the results of the MTT, BrdU, and Transwell assays, the miR-101-3p mimics significantly suppressed HCC cell proliferation and reduced the proliferation (Fig. 7C, D), migration (Fig. 7E), and invasion (Fig. 7F) abilities of Huh7 cells, which were reversed by pcDNA3.1-PDZK1 transfection. This evidence concerns the gene PDZK1 and hepatocellular carcinoma.