It is effective in the screening, diagnosis, monitoring, and prognosis of BC, and the methods involve the use of nuclear matrix protein 22 (NMP22) [11], bladder tumor antigen-associated antigen (BTA stat and BTA trak) [12], AdxBladder [13], and Oncuria [14] Various methods have been developed that can screen proteins on a large scale. The gene discussed is NUMA1; the disease is breast cancer.