WNT5A and Hepatic fibrosis: While in other cases, the upregulation of Wnt5a has been implicated in aggravating a variety of tissue fibrosis and scar formation, such as cardiac fibrosis under pressure overload [25], myocardial fibrosis following myocardial infarction [26], atrial fibrosis [25], keloid scarring caused by aberrant genetic activation [13], idiopathic pulmonary fibrosis [27], renal fibrosis [28], and liver fibrosis [29].