A similar hypoxia-induced coexpression of CD133 and HIF-1α in glioma cells has been reported by other groups [131, 132], and it was shown to be associated with enhanced chemoresistance, invasiveness, and EMT, which is in line with results obtained with cell lines derived from pancreatic [133] and ovarian cancer samples [134]. This evidence concerns the gene PROM1 and ovarian carcinoma.