IL6 and breast carcinoma: In basal-like breast carcinoma cells with p53 deficiency, which leads to an autocrine interleukin (IL)-6 loop driving cell reprogramming, IL-6 was found to regulate PROM1 expression by inducing PROM1 P1 promoter demethylation that resulted in enhanced transcription and, in parallel, an increased methylation of the PROM1 P2 promoter that carries putative repressor sites [125].