Elevated levels of HIF-1α and HIF-2α were shown to simulated the transcription of the PROM1 gene at the P5 promoter in colon cancer cells; specifically, it was initiated by the binding of the HIF-1-Elk1 complex to the E-twenty-six (ETS)-binding motif present in P5 [113, 136]. Here, PROM1 is linked to colonic neoplasm.