Interestingly, in hepatocellular carcinoma, a functional cooperation between IL-6/signal transducer and activator of transcription 3 (STAT3) signaling and nuclear factor kappa-light-chain-enhancer of activated B cells and HIF-1α was reported to upregulate CD133 expression that was associated with poor prognosis [138]. This evidence concerns the gene STAT3 and hepatocellular carcinoma.