AFF1 and malignant colon neoplasm: PROM1 gene was found to be a target of the MLL fusion-associated gene AF4 (MLL-AF4) in human colon cancer Caco-2 cells [120] and in some MLL cells [118], where its transcription is upregulated through H3K79 methylation and the presence of an intragenic H3K79me2/3 enhancer element.