ALT ≥ 2 × ULN (inflammation: p < 0.001, OR = 4.328; fibrosis: p < 0.001, OR = 3.555) and PLT (inflammation: p = 0.007, OR = 0.992; fibrosis: p = 0.001, OR = 0.991) were independently associated with significant liver inflammation and fibrosis in the HBeAg-negative group. This evidence concerns the gene GPT and Hepatitis.