A more recent meta-analysis did not find the total lymphocyte cell count significantly altered in FEP or drug-naïve schizophrenia patients but noted elevated blood Th signature cytokines IFN-γ, TGF-β, and IL-17 [69], which, together with several other earlier meta-analyses on blood cytokines, jointly imply imbalanced Th polarization in FEP patients [69–71]. This evidence concerns the gene TGFB1 and schizophrenia.