The mitochondrial YgfZ ortholog (IBA57) is implicated in the synthesis of Fe/S proteins and mutations in the IBA57 gene have been linked with hereditary spastic paraplegia (Lossos et al, 2015) and a metabolic syndrome presenting with severe myopathy and encephalopathy(Ajit Bolar et al, 2013). This evidence concerns the gene IBA57 and hereditary spastic paraplegia.