Axonal injury and rmTBI might trigger molecular pathways that result in the aggregation of proteins prone to pathological accumulation in neurodegenerative disease, including phosphorylated tau (p-tau), TAR DNA-binding protein 43 kDa, α-synuclein, and amyloid-ß, thereby increasing the likelihood of frontotemporal lobar degeneration, Lewy body disease, or AD27,29. Here, MAPT is linked to neurodegenerative disease.