Pathways downregulated in inclusion-bearing neurons related to the synapse (glutamatergic synapse, dopaminergic synapse, GABAergic synapse, retrograde endocannabinoid signaling, endocytosis), mitochondria (NADH dehydrogenase, NADH:ubiquinone reductase, oxidative phosphorylation), metabolism (citrate cycle), cell signaling (phosphatidylinositol signaling system), RNA (eIF-3, RNA transport), ubiquitin-proteasome (proteasome, family T1 proteasome family, ubiquitin mediated proteolysis), and neurodegenerative disease (Parkinson’s, Alzheimer’s, Huntington’s). This evidence concerns the gene ENSG00000254051 and neurodegenerative disease.