Moreover, METTL3 was identified to positively modulate gemcitabine (GEM) sensitivity of PC via DBH-AS1/miR-3163/USP44, and low expression level of METTL3 was closely related with GEM resistance.394 Upregulated METTL14 was observed in GEM-resistant PC cells, which was induced by p65 and downstream facilitated cytidine deaminase (CDA) expression to inactivate GEM in PC. This evidence concerns the gene USP44 and pachyonychia congenita.