ESR1 and rheumatoid arthritis: For instance, METTL3 is significantly upregulated in RA patients and positively associated with CRP and ESR, the two common markers of RA disease activity.385 In systemic lupus erythematosus (SLE), decreased m5C level and low NSUN2 expression are found in CD4 + T cells, and hypermethylated m5C-modified upregulated genes in SLE are enriched in inflammatory pathways.386 Significantly, in DC-dependent inflammatory response, m6A-mediated glycolytic reprogramming is critical for feedback-control of DC migration.