Knockdown of METTL3 using short hairpin RNA improved sensitivity to anticancer reagents such as gemcitabine, 5-fluorouracil, cisplatin and irradiation in pancreas cancer (PC).430 Suppression of METTL3 restored chemosensitivity and attenuated CML cells viability.431 Nevertheless, few studies have ever investigated the utility of METTL3 inhibitors in overcoming chemoresistance. This evidence concerns the gene METTL3 and pachyonychia congenita.