ALKBH5 and melanoma: Deficiency of ALKBH5 induced downregulation of MCT4 expression and intra-tumoral lactate content, which negatively influenced polymorphonuclear myeloid derived cells and Tregs.404 Several bioinformatic studies have underlined the intimate connection between m6A modification and immunotherapy resistance.405 Moreover, loss of A-to-I editor ADAR1 significantly augmented anti-PD-1 treatment in melanoma and CRC.