Additionally, METTL3 knockdown abrogated AK4 expression and drug resistance.343 Also, METTL3 exerts inhibitive role in mitochondrial apoptosis via AKT signaling pathway in EC.344 METTL14 plays a pivotal part in regulating mitochondrial homeostasis in CRC via m6A/YTHDC2/miR-17-5p/MFN2 axis. This evidence concerns the gene METTL14 and colorectal carcinoma.