In NSCLC, METTL3-induced m6A methylation on DCP2 mRNA accelerates its degradation, which activates mitochondrial autophagy through the Pink1-Parkin pathway, inducing resistance to cisplatin and etoposide.342 In amoxifen-resistant BRCA cells, METTL3 was overexpressed and contributed to upregulation of AK4, which stimulating ROS production and p38 phosphorylation, further suppressing mitochondrial apoptosis to desensitize tamoxifen. This evidence concerns the gene METTL3 and non-small cell lung carcinoma.