METTL3 and colorectal carcinoma: IGF2BP2 deficiency accelerated degradation of Bmi1 mRNA, relieving its depression on mitochondria-related genes, thus impaired quiescence state and functions of HSCs.351 A novel RNA-binding protein, RALY, a member of HNRNPC subfamily, augmented pri-miRNA processing via the METTL3-mediated m6A modification, further reprogrammed mitochondrial metabolism by downregulating the electron transport chain (ETC) genes in CRC cells.