Upregulated FTO in oral squamous cell carcinoma played a pivotal part in arecoline-induced stemness and chemoresistance to cisplatin.432 Depletion of FTO sensitized breast cancer to doxorubicin via suppressing de novo synthesis of fatty acid.433 Specifically, FTO was revealed to facilitate GBM resistance to temozolomide (TMZ), and the inhibitor R-2HG demonstrated a synergistic effect with TMZ in suppressing proliferation of FTO-high glioma cells.412. This evidence concerns the gene FTO and central nervous system cancer.