PPARGC1A and atherosclerosis: In mechanism, m6A methylation contributes to enhanced expression of HDGF, which increases glycolysis and lipids accumulation in M1, therefore aggravating the progression of atherosclerosis.388 And METTL3-meidated m6A of PGC-1α mRNA is involved in mitochondrial dysfunction and oxLDL-induced inflammation in monocytes.340 Although there are few studies on RNA modifications regulating inflammatory and autoimmune diseases in the aspect of immunometabolism.