YTHDF2 and leukemia: In SCLC cell line, meclofenamic acid (MA) treatment significantly induced attenuated glycolysis and enhanced mitochondrial metabolism.246 R-2-hydroxyglutarate (R-2HG) represses aerobic glycolysis of leukemia cells via abrogating m6A/YTHDF2-mediated upregulation of PFKP and LDHB, thus inhibiting leukemogenesis in vivo.247 Besides, FTO elevates TFs c-Jun, JunB, and C/EBPβ to upregulate glycolysis-related genes in melanoma, contributing to escaping immune surveillance.