METTL14 and colorectal carcinoma: In CRC, METTL14 repressed glycolysis via YTHDF2-dependent processing of pri-miR-6769b and pri-miR-499a, which attenuated SLC2A3 and PGAM1 expression, respectively.231 In HCC, METTL14 stabilizes USP48 mRNA, which mediated deubiquitination at the K33 and K128 sites of SIRT6, thus hindered glycolytic reprogramming.232 In RCC, METTL14 attenuated stability of BPTF mRNA, which constituted super-enhancers that activated downstream glycolysis-related genes like ENO2 and SRC.233 Lin et al. proposed that METTL14 positively regulated LHPP expression to restrain aerobic glycolysis of GC.234