CD8A and neoplasm: Besides, cholesterol uptake activates PD-1 expression in tumor-infiltrating CD8 + T cells, which in turn facilitates FAO and lipolysis.374 Extracellular fatty acids are more effectively consumed by Treg cells than effector T cells, which eventually supports Treg accumulation.375 Oxidized lipids restrain cross-representation in DCs376 and enhanced uptake of fatty acids and peroxidation lead to dysfunctional state of tumor-derived DCs.377 But the role of RNA modifications in these cellular processes has not been identified yet.