In LC, overexpressed YTHDF2 binds to m6A sites on 3′-UTR of G6PD mRNA to promotes its translation, enhancing PPP flux,257 and Chen et al. proposed that YTHDF2 enhanced PPP via reducing G6PD ubiquitination by circ_0003215/miR-663b/DLG4 axis.258 In CRC, YTHDF2 is capable to stabilize mRNA of GSK3 to inhibit glycogen synthesis and facilitate glycogenolysis.259 Also, YTHDF2-mediated degradation of STEAP3 mRNA attenuated STEAP3-induced phosphorylation and inactivation of GSK3β in CRC.260. This evidence concerns the gene YTHDF2 and colorectal carcinoma.