YTHDF3 and hepatocellular carcinoma: YTHDF3 facilitated aerobic glycolysis of HCC cells by elevating PFKL expression, and PFKL in turn upregulated YTHDF3 through reducing its ubiquitination.261 In PDAC, YTHDF3-mediated destabilization of lncRNA DICER1-AS1 contributes to enhancing expression of glycolytic genes like LDHA, HK2, PGK1, and SLC2A1,262 while YTHDF3 targeted m6A-modified PGK1 mRNA to exert a stabilizing role in OS.263 IGF2BP1 was highly expressed in GC tissue and associated with poor prognosis for GC patients.