Depletion of RALY demonstrated effective inhibition of tumor growth and development in vivo and in organoid models.352 In glioma, YTHDF1 participated in c-MYC-induced restraint on mitochondrial autophagy by directly interacting with FDX1 and upregulated its expression, which was closely correlated with malignant phenotypes and clinical prognosis.353 Highly-expressed HNRNPA2B1 served as an adverse prognostic factor in MM. This evidence concerns the gene YTHDF1 and neoplasm.