ALKBH5 and central nervous system cancer: ALKBH5 enhanced stability of G6PD mRNA, thereby activating PPP and promoting proliferation of glioma cells.252 In HER2 resistant BRCA cells, ALKBH5 stimulated glycolysis via protecting GLUT4 mRNA from YTHDF2-mediated decay.253 However, in PTC, knockdown of ALKBH5 accelerates glycolysis through upregulating circNRIP1 and consequently increased PKM2 expression.254 Zhao et al. discovered that overexpressed ALKBH5 elevated expression level of UBR7, which inhibited glycolysis by indirectly suppressing HK2 expression through Nrf2/Bach1 axis.255