HK1 and cancer: While in cancer cells, glycolysis had priority over mitochondrial respiration even with sufficient oxygen supply, known as Warburg effect or aerobic glycolysis.192 The key glycolytic enzymes, such as hexokinase (HK), enolase (ENO), Aldolase A (ALDOA), pyruvate kinase isozyme M1/2 (PKM1/2), pyruvate dehydrogenase kinase (PDK), lactate dehydrogenase (LDH) and glucose transporter (GLUT) are crucial targets of RNA modifications in various pathological processes.