FTO and thyroid gland papillary carcinoma: Recently, Liu et al. reported that overexpression of FTO could partially reverse E6E7-induced improvement on HK2 in CC.249 In LUAD, Wnt signaling induces downregulation of FTO, thus increased m6A level leads to enhanced YTHDF1-mediated translation of c-MYC and subsequently increases glycolysis.250 FTO diminishes IGF2BP2-dependent stabilization of APOE mRNA, thus restrains glycolysis and growth of papillary thyroid cancer (PTC).251