CS1/2-induced FTO inhibition not only attenuates leukemia stem cell self-renewal, but reprograms immune responses by downregulating expression of immune checkpoint gene, which overcomes HMA-induced immune evasion and sensitizes leukemia cells to T cell cytotoxicity.402 Also, Dac15 restores functions of CD8 + T cells, blocks FTO-mediated immune evasion, and synergizes with anti-PD-1 blockade.248 Recently, progresses have been made in more tumor types rather than AML and glioma. The gene discussed is FTO; the disease is acute myeloid leukemia.