VHL and nonpapillary renal cell carcinoma: FTO-mediated m6A demethylation upregulated expression of the glutamine transporter SLC1A5, and FTO inhibition exclusively suppressed the proliferation and vitality of VHL-deficient ccRCC cells independent of HIF.357 Han et al. suggested that m6A modification exerted a significant role in the antitumor efficacy of glutaminolysis inhibition in CRC cells.