ALKBH5 and cervical squamous cell carcinoma: FTO-dependent m6A demethylation indirectly elevates SREBP1c expression, thus activating downstream lipogenic genes.303 Knockdown of FTO markedly enhanced m6A abundance of FASN mRNA and promoted YTHDF2-mediated decay, further reduced protein levels of ACC1 and ACLY, which suppressed de novo lipogenesis in HepG2 cells.325 In EC, mechanism study revealed that FTO promoted the formation of lipid droplets by enhancing HSD17B11 expression.326 ALKBH5 was downregulated in cervical squamous cell carcinoma (CESC) and predicted an unfavorable prognosis.