The donor brain used for these tomograms (Fig. 1a) had a high level of Alzheimer’s disease neuropathologic change, including a severe burden of tau and amyloid-β with TMEM106B present in the absence of TDP-43 or α-synuclein aggregates in the middle frontal cortex (Supplementary Fig. 5). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.