In the ALLG NBCR cohort, 121 patients aged 18–59 years with newly diagnosed FLT3-ITD (allelic ratio ≥0.05; n = 103) and FLT3-TKD (n = 19; 1 had concurrent ITD) mutated AML treated with intensive chemotherapy without midostaurin were identified. The gene discussed is FLT3; the disease is acute myeloid leukemia.