In breast cancer cells, TGF-β-induced p38 kinase activity can phosphorylate NR4A1 and TGF-β-induced β-catenin can transactivate NR4A1 expression via formation of β-catenin/TCF/LEF complex and its binding to NR4A1 promoter [63]. This evidence concerns the gene HNF4A and breast carcinoma.