NR4A2 and Familial prostate cancer: Previously, we have identified that NURR1 manifests a common upregulation in both the prostate cancer stem cells (PCSCs) -enriched 3D-cultured prostatospheroids derived from different prostate cancer cell lines and a CRPC xenograft model (CRPC-VCaP) based on the castration-relapse growth of VCaP cells in castrated mice, suggesting that NURR1 might perform an oncogenic role in prostate cancer [34].