NR4A2 and Familial prostate cancer: Results showed that NURR1 overexpression or its activation by C-DIM-12 could significantly enhance spheroid formation capacities in prostate cancer cells (VCaP, LNCaP and DU 145), whereas its knockdown/knockout or suppression of Wnt signal by IWP-2 could suppress the spheroid formation capacities in prostate cancer cells (Fig. 4A–D).