Together, these results suggest that besides transactivation of CTNNB1, NURR1 could also activate the β-catenin-mediated signaling in prostate cancer cells via its activation (dephosphorylation) and enhanced nuclear accumulation; and through this activation, it could enhance/promote expression of its interacting transcription factors TCF and activate downstream signaling/targets with no significant change of Wnt signals. This evidence concerns the gene CTNNB1 and Familial prostate cancer.