However, no significant change was observed for ARHGEF39 gene, upstream of EBNA2 binding region in the CA9 promoter/enhancer region in response to either ΔEBNA2 or wild-type EBV infection of naïve B-lymphocytes (S7D Fig), indicating that EBNA2 might only be involved in downstream CA9 regulation in that genomic region. Here, CA9 is linked to Epstein-Barr virus infection.