To explore the potential role of IFN signaling in suppressing cardiac reprogramming, we employed short hairpin RNAs (shRNA) to specifically knockdown (KD) the interferon receptors (IFNAR) genes Ifnar1 or Ifnar2 (IFNAR were formed by two chains encoded by Ifnar1 and Ifnar2) to reduce the response of IFN-α/β in MICFs isolated from mice at Day 6 post myocardial infarction (MI D6), with the expression of MGT or MGTMyoS (Fig. S2A). The gene discussed is IFNAR2; the disease is myocardial infarction.